2012.3

since 02. July 2012

 

C O N T E N T S   3.2012

 

 

 

 

 

COMMENTS ON THE ARTICLES


ORIGINAL ARTICLES


Emina Kasumagić-Halilovic, Nermina Ovcina-Kurtovic
Serum levels of interleukin-1 (IL-1α, IL-1β) in patients with alopecia areata
Stężenie Interleukiny-1 (IL-1α, IL-1β) u chorych na łysienie plackowate

      Our Dermatol Online 2012; 3(3): 161-163          DOI: 10.7241/ourd.20123.37

[abstract-English, P olish] , [article in English],   [PDF], [HTML]

Neerja Puri, Tejinder Kaur
A study of nail changes in various dermatosis in Punjab, India
Zmiany paznokciowe w różnych dermatozach w Punjab, India

      Our Dermatol Online 2012; 3(3): 164-170          DOI: 10.7241/ourd.20123.38

[abstract-English, Poli sh] , [article in English],   [PDF], [HTML]

 
Comment by: Dr. Leonel Fierro, Dr. Alexandro Bonifaz  P hD

      Our Dermatol Online 2012; 3(3): 171          DOI: 10.7241/ourd.20123.38.1

[article in English],   [PDF], [HTML]

Neerja Puri
Onchomycosis – a clinical and mycological study of 75 cases
Grzybica paznokci – kliniczne i mikologiczne badanie 75 przypadków

      Our Dermatol Online 2012; 3(3): 172-177          DOI: 10.7241/ourd.20123.39

[abstract-English,  Polish] , [article in English],   [PDF], [HTML]

Muhammad Javed
Clinical spectrum of neonatal skin disorders at Hamdard University Hospital Karachi, Pakistan
Kliniczne spektrum skóry noworodków w Szpitalu Uniwersyteckim Hamdard w Karachi, Pakistan

      Our Dermatol Online 2012; 3(3): 178-180          DOI: 10.7241/ourd.20123.40

[abstract-English, Polish] , [article in English],   [PDF], [HTML]

Farah Sameem, Iffat Hassan, Imran Majid, Qazi Masood
Low dose penicillamine in systemic sclerosis: is it effective?
Niskie dawki penicylaminy w twardzinie układowej: czy są efektywne?
      Our Dermatol Online 2012; 3(3): 181-183          DOI: 10.7241/ourd.20123.41

[abstract-English, Poli sh] , [article in English],   [PDF], [HTML]

Neerja Puri, Asha Puri
A comparative study on 100% tca versus 88% phenol for the treatment of vitiligo
Badanie porównawcze 100% TCA w stosunku do 88% fenolu w leczeniu bielactwa
      Our Dermatol Online 2012; 3(3): 184-186          DOI: 10.7241/ourd.20123.42

[abstract-English, Poli sh] , [article in English],   [PDF], [HTML]

 
Comment by: Cheng-Che E. Lan, MD, PhD

      Our Dermatol Online 2012; 3(3): 187          DOI: 10.7241/ourd.20123.42.1

[article in English],   [PDF], [HTML]

Nagat Sobhy, Adel El-Shafaei, Nanis Kamal
Study of fractional ablative laser in surgical and post traumatic scar
Badanie nad wykorzystaniem ablacyjnego lasera frakcyjnego w chirurgicznych i pourazowych bliznach

      Our Dermatol Online 2012; 3(3): 188-195          DOI: 10.7241/ourd.20123.43

[abstract-English,  Polish] , [article in English],   [PDF], [HTML]

Nafie A. Al-Muslet, Amel Ibrahim Khalid
Clinical evaluation of low level laser therapy in treatment of cutaneous leishmaniasis
Kliniczna ocena laseroterapii w leczeniu skórnej postaci leiszmaniozy

      Our Dermatol Online 2012; 3(3): 196-201          DOI: 10.7241/ourd.20123.44

[abstract-English,  Polish] , [article in English],   [PDF], [HTML]


CASE REPORTS


Ana Maria Abreu Velez, A. Deo Klein, Michael S. Howard
Immunologic findings in central centrifugal cicatricial alopecia
Immunologiczne wyniki w centralnym ośrodkowym bliznowaciejącym łysieniu

      Our Dermatol Online 2012; 3(3): 202-205          DOI: 10.7241/ourd.20123.45

[abstract-English, Pol ish] , [article in English],   [PDF], [HTML]

Sundaramoorthy Srinivasan
Enigmatic nodules on skin – a case report
Enigmatyczne guzki na skórze – prezentacja przypadku

      Our Dermatol Online 2012; 3(3): 206-209          DOI: 10.7241/ourd.20123.46

[abstract-English, Po lish] , [article in English],   [PDF], [HTML]

Chaitanya Varma, Shrikiran Aroor, Suneel C Mundkur, Karthick Annamalai
Kawasaki disease with peripheral gangrene and autoamputation – an extremely rare complication: a case report
Choroba Kawasaki z obwodową zgorzelą i autoamputacją – niezwykle rzadka komplikacja: opis przypadku

      Our Dermatol Online 2012; 3(3): 210-211          DOI: 10.7241/ourd.20123.47

[abstract-Engli sh, Polish] , [article in English],   [PDF], [HTML]

Seema Srinivasa, Metikurke Vijayashankar
Successful treatment of infundibulofolliculitis with topical tretinoin. Report of a case
Skuteczne leczenie infundibulofolliculitis za pomocą miejscowej tretinoiny. Opis przypadku

      Our Dermatol Online 2012; 3(3): 212-214          DOI: 10.7241/ourd.20123.48

[abstract-English, P olish] , [article in English],   [PDF], [HTML] 

Hariharasubramony Ambika, Chankramath Sujatha
Hyperkeratosis of nipple and areola
Hiperkeratoza brodawki sutka i otoczki

      Our Dermatol Online 2012; 3(3): 215-216          DOI: 10.7241/ourd.20123.49

[abstract-English, Po lish] , [article in English],   [PDF], [HTML]

Lawrence Chukwudi Nwabudike
Atopic Dermatitis and Homeopathy
Atopowe zapalenie skory a homeopatia

      Our Dermatol Online 2012; 3(3): 217-220          DOI: 10.7241/ourd.20123.50

[abstract-English, Polish] , [article in English],   [PDF], [HTML]


OPINION ARTICLE


Khalid Al Aboud
The selection of the types of shoes and its impact on the skin of the feet
Wybór rodzajów obuwia i jego wpływ na skórę stóp

      Our Dermatol Online 2012; 3(3): 221-223          DOI: 10.7241/ourd.20123.51

[abstract-English, Poli sh] , [article in English],   [PDF], [HTML]

 
Comment by: Piotr Brzezinski, MD, PhD

      Our Dermatol Online 2012; 3(3): 224-225          DOI: 10.7241/ourd.20123.51.1

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Comment by: Dr. Marko Vok

      Our Dermatol Online 2012; 3(3): 226          DOI: 10.7241/ourd.20123.51.2

[article in English],   [PDF], [HTML]


CLINICAL IMAGES


Iffat Hassan, Peerzada Sajad
Mayerson’s phenomenon in a cutaneous neurofibroma
Zjawisko Meyersona w przebiegu nerwiakowłókniaka

      Our Dermatol Online 2012; 3(3): 227          DOI: 10.7241/ourd.20123.52

[article in English],   [PDF], [HTML] 


LETTERS TO THE EDITOR


Pratyusha Kolanuvada, Chankramath Sujatha, Hariharasubramony Ambika
Disseminated superficial porokeratosis and anetoderma developing after acute pancreatitis
Rozwój rozsianej powierzchownej porokeratozy i anetodermii po ostrym zapaleniu trzustki

      Our Dermatol Online 2012; 3(3): 228-230          DOI: 10.7241/ourd.20123.53

[article in English],   [PDF], [HTML]

Nithya Raghunath, Sreekar Harinatha, Sreeharsha Harinatha
Purpura following a rare etiology; a diagnostic dilemmaon the back
Plamica postępująca o rzadkiej etiologii; diagnostyczny dylemat

      Our Dermatol Online 2012; 3(3): 231          DOI: 10.7241/ourd.20123.54

[article in English],   [PDF], [HTML]

Anca Chiriac, Liliana Foia, Claudia Miron
Vitiligo – Anti-thyroid peroxidase antibody
Bielactwo – przeciwciała przeciwko peroksydazie tarczycowej

      Our Dermatol Online 2012; 3(3): 232-233          DOI: 10.7241/ourd.20123.55

[article in English],   [PDF], [HTML]

Chaitanya Varma, Shrikiran Aroor, Suneel C. Mundkur
An atypical giant mantoux reaction
Nietypowa olbrzymia reakcja mantoux

      Our Dermatol Online 2012; 3(3): 234          DOI: 10.7241/ourd.20123.56

[article in English],   [PDF], [HTML]

Nithya Raghunath, Sreekar Harinatha, Sreeharsha Harinatha
Crimary lingual tuberculosis, a rare case report
Pierwotna gruźlica języka, rzadki opis przypadku

      Our Dermatol Online 2012; 3(3): 235-236          DOI: 10.7241/ourd.20123.57

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DERMATOLOGY EPONYMS


Khalid Al Aboud
The problem of synonyms; Multiple Symmetric Lipomatosis, as an example
Problem synonimów; Multiple Symmetric Lipomatosis, jako przykład

      Our Dermatol Online 2012; 3(3): 237-238          DOI: 10.7241/ourd.20123.58

[article in English],   [PDF], [HTML]

Khalid Al Aboud
Blahoslav Bednar (1916-1998) and the tumor which bears his name
Blahoslav Bednar (1916-1998) i guz, który nosi jego imię

      Our Dermatol Online 2012; 3(3): 239-240          DOI: 10.7241/ourd.20122.59

[article in English],   [PDF], [HTML]

Khalid Al Aboud
André Nanta (1883-1963) and the nevus which bears his name
André Nanta (1883-1963) i znamię, które nosi jego imię

      Our Dermatol Online 2012; 3(3): 241-242          DOI: 10.7241/ourd.20123.60

[article in English],   [PDF], [HTML]

Piotr Brzezinski, Ahmad Thabit Sinjab, Emili Masferrer, Priya Gopie, Vijay Naraysingh, Toshiyuki Yamamoto, Ali Rezaei-Matehkolaei, Hossein Mirhendi, Carol A. Kauffman, Abdülkadir Burak Cankaya, Americo Testa, Maria do Rosário Rodrigues Silva
Dermatology Eponyms – sign –Lexicon (G)
      Our Dermatol Online 2012; 3(3): 243-257          DOI: 10.7241/ourd.20123.61

[abstract-English, Poli sh] , [article in English, Polish],   [PDF], [HTML]





COMMENTS ON THE ARTICLES

SERUM LEVELS OF INTERLEUKIN-1 (IL-1Α, IL-1Β) IN PATIENTS WITH ALOPECIA AREATA


Dr. Mohamed Wael Daboul (Syrian Arab Republic)
Interlukin-1 is a polypeptide produced post injuries, infections, and when the body is exposed to different antigens. It is not only produced by lymphocytes but macrophages, endothelial cells, and fibroblasts as well. Interlukin-1 expresses its function either locally (within the cytoplasmic membrane). This type of interleukins is called Interlukin-1 alpha. An other type of interlukin-1 being excreted into the system and it is then called, Interlukin-1 beta. Both interlukin-1 alpha and Beta are distinct in their genetic characteristics and have limited similarities in their peptide structures. They still both share vital activities and the same receptors. Interlukin-1 alpha remains associated with the cellular membrane stimulating local changes in the surrounding tissues, without causing any systemic responses. While interlukine-1 beta, gains access into the circulation, so it acts like hormones by stimulating wide spectrum of systemic changes in neural, metabolic, and endocrinal systems. Interlukine-1 beta may stimulate the lymphocytic cells and it plays an important rule in the immunological response. It is considered an essential mediator in the inflammatory incidence. Based on the previous introduction and considering Alopecia areata (AA) as a disease with multifactor causes, one may speculate that not only interleukins-1 alpha but both interleukins-1 alpha and beta should have a significant increase in their levels if they have a role to play in the pathophysiology of the disease. The surprise in this study is that the results showed a significant elevation only in the localized alpha type but not the systemic beta type. Although this study was great in casting the light on the interleukins-1 α and its activation to the immune system and through that its pathophysiological role in AA, it still lacks an explanatory answer for the none significant elevation in interleukin-1 B.
 
Daisuke Tsuruta, MD, PhD and Koji Sugawara, MD, PhD (Japan)
Interleukin-1 (IL-1) is one of major inflammatory cytokines. IL-1 was originally identified as intrinsic pyrogen and lymphocyte stimulating factor. It works by binding to its receptor, IL-1 receptor (IL-1R). The binding of IL-1 with IL-1R triggers nuclear factor (NF)-kB and mitogen activated kinase signaling pathway, and induces several important events to maintain cellular function both in vivo and in vitro.1 Kasumagić-Halilovic and Ovcina-Kurtovic presented excellent study associated with slight, but actual elevation of IL-1a in alopecia areata.2 This work supports several previous in vivo and in vitro studies in which elevation of IL-1a may directly or indirectly inhibit hair growth in alopecia areata (see references 11-15 of their study). Although further large population study is required to convince their data, the relationhship of IL-1a to alopecia areata is promising. Several questions may be provoked from this study. 1) Which cells are sources of IL-1a? 2) What and how is the trigger of such IL-1a up-regulation? 3) Does antagonization of IL-1a work for the treatment of alopecia areata? I mean, does anakinra, IL-1R antagonist,3 work well for alopecia areata? We can confirm the action of anakinra when rheumatoid arthritis patient is accidentally associated with alopecia areata. 4) Which stage of anagen (stage I-VI) does IL-1a work for? These research subjects must be provoked by this interesting study!!

REFERENCES
1. Stylianou E and Saklatvala J. Interleukin-1. Int J Biochem Cell Biol 1998, 30; 1075-9.
2. Kasumagić-Halilovic E, Ovcina-Kurtovic N. Serum levels of interleukin-1 (IKL-1A, IL-1B) in patients with alopecia areata. Our Dermatol Online 2012, 3: 161-163.
3. Goldbach-Mansky R. Immunology in clinic review series; focus on autoinflammatory diseases: update on monogenic autoinflammatory diseases: the role of interleukin (IL)-1 and an emerging role for cytokines beyond IL-1. Clin Exp Immunol 2012, 167: 391-404.

Daisuke Tsuruta, MD, PhD and Koji Sugawara, MD, PhD
Department of Dermatology, Osaka City University Graduate School of Medicine
1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585 Japan
Tel. +81 6 6645 3826
Fax +81 6 6645 3828
e-mail. dtsuruta@med.osaka-cu.ac.jp
 
 
Dr. Felix J. Tapia (Venezuela)
Serum concentrations of IL-1 were determined by ELISA in forty patients with alopecia areata (AA) and twenty healthy controls. The results show a significant increase of IL-1 in patients with AA as compared with controls. This increase of IL-1 may be the result of activation of epithelial cell inflammasome, a molecular platform composed of NOD-like receptors (NLR), adaptor molecules such as ASC and pro-caspase-1, which trigger the activation of caspase-1 thus promoting the production of interleukin (IL)-1ß and IL-18. The function of the inflammasome is to sense danger signals, and mount the inflammatory cascade. In AA, one may speculate that an unknown antigen trigger the disease and activate the inflammasome or probably mutations in NOD-like receptors cause AA through a malfunction of the inflammasome. Since the use of contact sensitizer such as 2,4-Dinitrochlorobenzene (DNCB) may heal lesions of AA, most probably a defect on the inflamasome may be involved in AA. The article by Kasumagic-Halilovic & Ovcina-Kurtovic shows some light for a better comprehension of AA, a hair loss autoimmune disease.

REFERENCES
1. Gaide O: Inflammasome in the Skin. In: The Inflammasomes Series Progress in Inflammation Research. Couillin, Isabelle; Pétrilli, Virginie; Martinon, Fabio (Eds.). Springer Basel 2011 pp. 133-149.
 

Ass. Prof. Miloš Jeseňák (Slovakia)
Another important topic. Authors found the possible role of pro-inflammatory cytokine IL-1 in the pathogenesis of alopecia areata. This is another dermatologic conditions with increasing data on its pathogenesis and development. The finding of increased concentration of IL-1 in this patients confirm the complex ongoing inflammatory background of this disease. it would be interesting to investigate the possible association between selected polymorphism of IL-1 gene and AA.
 
 
Dr. Manuel Valdebran (Dominican Republic)
Alopecia areata is a disease in which there is a collapse of the hair follicule immune privilege. Current hypothesis remarks the role of interferon γ and substance P up-regulating the expression of MHC class Ia in human hair follicule epithelium exposing follicle associated antigens to CD8 + T cells. If costimulatory signals and help from other cells such as CD4+ T cells and mast cells are provided, the lymphocytic infiltrates could attack the hair follicle.1 The authors have done a remarkable job stressing the role of IL-1α and IL-Iβ in the cascade of inflammation in alopecia areata. Further research has to be done to validate these findings and their roles in the inflammatory cascade.

REFERENCES
1. Gilhar A, Etzioni A, Paus R: Alopecia Areata. N Engl J Med. 2012; 366: 1515-1525.

 
 
 
A STUDY OF NAIL CHANGES IN VARIOUS DERMATOSIS
 
Dr. Jorge Génesis López-Granja (Belize)
Thumbs up for the authors! I believe this study reminds us about the importance of including nails as part of the physical examination. As the authors point out the exam of nails is very cost-effective: we do not need more than good light, a magnifying glass and decent knowledge of nail affections. I am convinced that a thorough physical examination and clinical history should remain the most important pillars in our practice if we want to give our patients what they expect from us: the best advice for their dermatological condition.
 
Prof. Lali Mekokishvili (Georgia)
I is me known, that I had to write only the comment, however, the article needs some proofreading. For the general interest, I allowed myself to correct some minor inaccuracies in the second page of the text (marked in red and green, please see an attachment). The authors have to indicate not only the number of patients examined, but also the study period; it is not clear how were able authors to get remarkably round numbers of patients (total number, number of cases concerning age, sex, occupation status etc.). Specifying the period of the study and the method of selection of patients, the authors will be able to clarify these issues.
 

 
 
ONCHOMYCOSIS – A CLINICAL AND MYCOLOGICAL STUDY OF 75 CASES
 
Prof. Roberto Arenas (Mexico)
In this paper some unusual data: high frecuency in females, predominate of fingernail affection and also high frecuency of molds.


 
IMMUNOLOGIC FINDINGS IN CENTRAL CENTRIFUGAL CICATRICIAL ALOPECIA
 
Ass. Prof. Miloš Jeseňák (Slovakia)
Nice article describing the possible immune mechanisms probably contributing to the pathogenesis of centrifugal alopecia. As this condition is quite frequent, the current knowledge of its pathogenesis is obscure and therefor this paper add new valuable data. it would be useful to confirm this result from one case reports also in a group of this patients.


 
ATOPIC DERMATITIS AND HOMEOPATHY
 
Ass. Prof. Miloš Jeseňák (Slovakia)
Alternative medicine is very popular among the patients and sometimes there is a tendency by the patients to substitute classical chronic antiallergic treatment by various tools of alternative medicine. The scientific reports about the efficacy of homeopathy in atopic dermatitis but also another allergic skin diseases are only few. The authors observed some effect of homeopathy in three patients with. However, the randomized studies are still missing.


THE SELECTION OF THE TYPES OF SHOES AND ITS IMPACT ON THE SKIN OF THE FEET
 
Dr.Rakesh Bharti (Indie)
Very well researched article on a subject which is usually ignored by both,the physician and the patient.A must read fro all physicians dealing wih Diabetes and Leprosy.



 
PRIMARY LINGUAL TUBERCULOSIS, A RARE CASE REPORT
 
Dr. Luiz Alberto Alves Mota (Brazil)
This article is interesting for all physicians and dentists. The fact we think about tuberculosis in cases of tumors of tongue, we could be increased the number of those diagnosed, mainly in endemic areas.
 


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