2014.1-24.familyhistory

                                                                                                                            article in PDF  
Our Dermatol Online.  2014; 5(1): 90-91
DOI:.  10.7241/ourd.20141.24
Date of submission:  14.09.2013 / acceptance: 28.10.2013
Conflicts of interest: None
 

A CASE-CONTROL STUDY OF EPIDEMIOLOGICAL IMPORTANCE RISK OF FAMILY HISTORY OF PSORIASIS

Anca Chiriac1, Caius Solovan2, Anca E Chiriac3, Liliana Foia4, Piotr Brzezinski5

1Dermato-Physiology Department, Apollonia University Iasi, Strada Muzicii nr 2, Iasi-700399, Romania
2Department of Dermatology, University of Medicine V Babes, Timisoara, Romania
3Medical student, University of Medicine and Pharmacy “Gr. T. Popa” Iasi, Romania
4Department of Biochemistry, University of Medicine and Pharmacy “Gr. T. Popa” Iasi, Romania.
5Department of Dermatology, 6th Military Support Unit, os. Lendowo 1N, 76270 Ust­ka, Poland
 

Corresponding author:  Ass. Prof. Anca Chirac    e-mail: ancachiriac@yahoo.com


 

Sir
We have conducted a case-control study to analyze the epidemiological importance risk of family history of psoriasis. The retrospective study was done on 1236 patients diagnosed with psoriasis on clinical and histopathological grounds, between 2004-2011, in an Out-patient Clinic in North-Eastern part of Romania.The sex ratio of psoriasis was 1.18:1 (male patients 54.13%, female patients 45.87%), median age at the diagnosis was 29.34±15.24SD; family history of psoriasis (by declaration) was 29.53% (Tabl. I).
 
Family history
Nr. cases
%
Absent
871
70.47%
Present
365
29.53%
First degree
200
16.18%
Children
16
1.29%
Parents
184
14.89%
Second degree
115
9.30%
Grand parents
36
2.91%
Grand children
9
0.73%
Brothers/sisters
70
5.66%
Third degree
36
2.91%
Grand-grand parents
3
0.24%
Uncle/aunt
33
2.67%
Fourth degree
14
1.13%
Cousins
14
1.13%
Total

1236

                  Table I. Results of the study.

Figure 1. Graphic of the distribution of family history among patients with psoriasis.
The problem of family history of psoriasis is a subject of debate, with great variability of results (Tabl. II), ranging from 7% to 60-70% depending on variable factors. Our study demonstrated an association of family history of 29.53%: 16.18% -first degree relatives; 9.30% second degree relatives; 2.91% third degree and 1.13% fourth degree relatives.
 
Study
Family history of psoriasis
Naldi et al[1] 1991
18.8% in parents and 3.25 in siblings
Naldi et al [2] 2001
7% in guttate psoriasis
Bahcetepe et al [3] 2013
56%
Na SJ et al [4] 2013
26%
Brunasso et al [5] 2013
28% in palmo-plantar plaque psoriasis
Clabaut et al [6] 2010
36-64%
Mahé E et al [7] 2004
25% in children with one parent diagnosed with psoriasis and 60-70%
if both parents have psoriasis

                  Table II. Results of the study.

 
REFERENCES
1. Naldi L, Parazzini F, Brevi A, Peserico A, Veller Fornasa C, Grosso G, et al. Family history, smoking habits, alcohol consumption and risk of psoriasis Br J Dermatol. 1992;127:212-7.
2. Naldi L, Peli L, Parazzini F, Carrel CF. Family history of psoriasis, stressful life events, and recent infectious disease are risk factors for a first episode of acute guttate psoriasis: results of a case-control study. J Am Acad Dermatol. 2001;44:433-8.
3. Bahcetepe N, Kutlubay Z, Yilmaz E, Tuzun Y, Eren B. The role of HLA antigens in the aetiology of psoriasis. Med Glas (Zenica). 2013;10:339-42.
4. Na SJ, Jo SJ, Youn JI. Clinical study on psoriasis patients for past 30 years (1982-2012) in Seoul National University Hospital Psoriasis Clinic. J Dermatol. 2013;40:731-5.
5. Brunasso AM, Puntoni M, Aberer W, Delfino C, Fancelli L, Massone C. Clinical and epidemiological comparison of patients affected by palmoplantar plaque psoriasis and palmoplantar pustulosis: a case series study. Br J Dermatol. 2013;168:1243-51.
6. Clabaut A, Viseux V: Société Française de Dermatologie Pédiatrique. [Management of childhood psoriasis]. Ann Dermatol. Venereol. 2010;137:408-15.
7. Mahé E. Psoriasis de l,enfant.J Pediatr Pueric. 2004;17:380-6.


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