article in PDF  
Our Dermatol Online.  2013; 4(3): 395-398
DOI:.  10.7241/ourd.20133.100
Date of submission:  24.03.2013 / acceptance: 11.05.2013
Conflicts of interest: None


Khalid Al Aboud1, Daifullah Al Aboud2

1Department of Public Health, King Faisal Hospital, Makkah, Saudi Arabia
2Dermatology department, Taif University, Taif, Saudi Arabia

Corresponding author:  Dr. Khalid Al Aboud    e-mail: amoa65@hotmail.com


We want to refresh the memory of our readers with some of the eponyms present in dermatopathology literature linked to the neural tissue, which we listed it concisely, in Table I [1-13]. The notes presented in the table are only inclusive and by no means conclusive, and are only intended to define only each eponyms.We utilized the information available for each eponyms from Wikipedia. However, the readers are free to refer to the references below for further reading about each eponyms.
Eponyms in the dermatopathology
literature linked to the neural
Antoni A and B [1]
These are histopathological pattern seen in schwannomas, consisting of hypercellular area (Antoni A) and hypercellular area (Antoni B).
Described in 1920, by Nils Ragnar Eugene Antoni (1887-1968), a Swedish physician who became doctor of medicine and associate professor of neurology at the Karolinska Institute, Stockholm, Sweden.
Bodian stain [2]
Special stain for nerve fibers and nerve endings. Named after David Bodian (1910-1992), (Fig. 1). Bodian received his Ph.D. in anatomy in 1934 and his M.D. in 1937 from the University of Chicago. He made major contributions to the knowledge of the basic structure of nerve cells.
Figure 1. David Bodian (1910 – 1992)

Bourneville disease [3]
This is not a common name for what is best known today as Tuberous Sclerosis
Complex (TSC). It is named after, Désiré-Magloire Bourneville (1840-1909), (Fig. 2), a French neurologist born in Garencières.
Figure 2. Désiré-Magloire Bourneville (1840-1909)

Carney complex [4]
Schwannomas may occur in association with Carney complex. The latter is an autosomal dominant condition comprising myxomas of the heart and skin, hyperpigmentation of the skin (lentiginosis), and endocrine overactivity. It is different from Carney triad, which describes the coexistence of several neoplasms, including: gastric epithelioid leiomyosarcoma, pulmonary chondroma, and extra-adrenal paraganglioma. Both are named after, J. Aidan Carney, (Fig. 3), a contemporary Professor of Pathology at Mayo Medical School.
Figure 3. J. Aidan Carney

Flexner-Wintersteiner rosette [5]
It is a peculiar microscopic pattern seen in retinoblastoma and certain other
ophthalmic tumors. They are true rosettes, which contain an empty lumen. They were first described by Simon Flexner (1863–1946), (Fig. 4), a physician, scientist, administrator, and professor of experimental pathology at the University of Pennsylvania. The observation of Flexner was later confirmed by, Hugo Wintersteiner (1865–1946) an Austrian ophthalmologist.
Figure 4. Simon Flexner (1863–1946)

Homer-Wright rosettes
Homer-Wright rosettes are a type of rosette in which differentiated tumor cells
surround the neuropil. Examples of tumors containing these are neuroblastoma,
medulloblastoma, andpinealoblastoma. They are considered „pseudo” in the sense they are not the true rosettes.
Lisch nodule [6]
It is a pigmented hamartomatous nodular aggregate of dendritic melanocytes affecting the iris, named after Austrian ophthalmologist Karl Lisch (1907-1999), (Fig. 5), who first recognized them in 1937.
Figure 5. Karl Lisch (1907-1999)

Masson neuronevus [7,8]
It is more commonly, known as neural nevus, or neurotized melanocytic nevus.
Named after, Claude L. Pierre Masson (1880-1959), (Fig. 6), French-born Canadian pathologist.
Figure 6. Claude L. Pierre Masson (1880-1959).
Reproduced from reference number 6.

Meissner’s corpuscles [9-11]
There are four major types of mechanoreceptors. These Meissner’s corpuscles,
Pacinian corpuscles, Ruffini endings and Merkel’s discs. Meissner’s corpuscles are named after, Georg Meissner (1829-1905), (Fig. 7), a German anatomist and physiologist.
Figure 7. Georg Meissner (1829-1905)
Pacinian corpuscles, are named after, Filippo Pacini (1812-1883), (Fig. 8), who was an Italian anatomist, posthumously famous for isolating the cholera bacillus Vibrio cholerae in 1854.
Figure 8. Filippo Pacini (1812 -1883)
Ruffini endings are named after, Angelo Ruffini (1864-1929), (Fig. 9). He was an Italian histologist and embryologist.
Figure 9. Angelo Ruffini (1864-1929)
Merkel’s discs are named after, Friedrich Sigmund Merkel (1845-1919), (Fig. 10). He was a leading German anatomist and histopathologist in the late 19th century.
Figure 10. Friedrich Sigmund Merkel (1845-1919)

Schwann cells [12]
Schwann cells are the principal glia of the peripheral nervous system. Named after Theodor Schwann (1810-1882), (Fig. 11), who was a German physiologist.
Figure 11. Theodor Schwann (1810-1882)
Verocay bodies [1]
A peculiar microscopic pattern seen in schwannomas, consisting of palisading cell around a cellular area. It is named after, Jose Juan Verocay (1876-1927), (Fig. 12). He was a Uruguayan physician who trained and worked for most of his adult life in Europe in the late nineteenth and early twentieth century.
Figure 12. Jose Juan Verocay (1876-1927)
von Recklinghausen syndrome
This is a synonym to neurofibromatosis. It is named after Friedrich Daniel von Recklinghausen (1833-1910), (Fig. 13), who was a German pathologist.
Figure 13. Friedrich Daniel von Recklinghausen (1833-1910)

                  Table I. Selected Eponyms in the dermatopathology literature linked to the neural tissues

1. Joshi R: Learning from eponyms: Jose Verocay and Verocay bodies, Antoni A and B areas, Nils Antoni and Schwannomas. Indian Dermatol Online J. 2012;3:215-9.
2. Palay SL: Professor David Bodian, M.D., Ph.D. (15 May 1910-18 September 1992). J Anat. 1994;185:673-6.
3. Broussolle E, Poirier J, Clarac F, Barbara JG: Figures and institutions of the neurological sciences in Paris from 1800 to 1950. Part III: neurology. Rev Neurol (Paris). 2012;168:301-20.
4. Seidl M, Zolnhofer G, Gunser S, Ennker J, Schäfer W, Tietze L: [Psammomatous melanotic schwannoma as indicator of a Carney complex]. Pathologe. 2013;12.
5. Tyler KL: Chapter 28: a history of bacterial meningitis. Handb Clin Neurol. 2010;95:417-33.
6. Lukacs A, Junk AK, Stefani FH, Kampik A, Schirren CG, Plewig G: [Lisch nodules. Markers of neurofibromatosis 1 and immunohistochemical references for neuroectodermal differentiation]. Hautarzt. 1997;48:38-41.
7. Al Aboud K, Al Aboud A: Eponyms in dermatology literature linked to Canada. Our Dermatol Online. 2013;4:113-6.
8. Al Aboud K: Eponyms linked to melanocytic nevi. Our Dermatol Online. 2012;3:374-6.
9. Bentivoglio M, Pacini P: Filippo Pacini: a determined observer. Brain Res Bull. 1995;38:161-5.
10. Eccles J: Letters from C. S. Sherrington, F.R.S., to Angelo Ruffini between 1896 and 1903. Notes Rec R Soc Lond. 1975;30:69-88.
11. Halata Z, Grim M, Bauman KI: Friedrich Sigmund Merkel and his „Merkel cell”, morphology, development, and physiology: review and new results. Anat Rec A Discov Mol Cell Evol Biol. 2003;271:225-39. 12. Schadewaldt H: [Nutrition and individual defense–historical considerations]. Zentralbl Hyg Umweltmed. 1991;191:302-6.
13. Brand RA: Biographical sketch: Friedrich Daniel von Recklinghausen, MD (1833-1910). Clin Orthop Relat Res. 2011;469:1225-6.



Other Resources

Our Dermatology Online

Current Issue
All Issues
Instruction for authors
Submit Manuscripts
Ethics in Publishing
For Reviewers
Editors & Publishers 
Contact Us