Large plexiform neurofibroma of the lower extremity

Mohammed Chaouche, Younes Barbach, Abdellah Dah Cherif, Sara Elloudi, Hanane Baybay, Fatima Zahra Mernissi

Department of Dermatology and Venereology, University Hospital Hassan II, Fez, Morocco

Corresponding author: Dr. Mohammed Chaouche, E-mail:

Submission: 23.01.2019; Acceptance: 25.03.2019

DOI: 10.7241/ourd.2019e.16

Cite this article: Chaouche M, Barbach Y, Cherif AD, Elloudi S, Baybay H, Mernissi FZ. Large plexiform neurofi broma of the lower extremity. Our Dermatol Online. 2019;10(e):e16.1.

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33-year-old female patient with a paternal family history of neurofibromatosis type 1 and a large plexiform neurofibroma of her right lower extremity present (Fig. 1). He was no longer able to wear normally, which in turn affected his activities of daily living.

Figure 1: Large plexiform neurofibroma of the lower extremity.


Plexiform neurofibroma is an uncommon variant of neurofibroma, a benign tumor of peripheral nerves (WHO grade I) [1], arising from a proliferation of all neural elements. Plexiform neurofibromas are essentially pathognomonic of neurofibromatosis type 1 (NF1). Unlike small sporadic localized neurofibromas and diffuse cutaneous neurofibromas, these tumors are at a significant risk of eventual malignant [2].


The examination of the patient was conducted according to the Declaration of Helsinki principles.


1. Kleinhues P, Cavenee WK. Tumours of the nervous system. In World Health Classi-cation of Tumours. Lyon:IARC Press Lyon;2000.

2. Huson SM, Hughes RA. The Neuro-bromatosis:A Pathogenetic and Clinical Overview. London:Chapman and Hall Medical;1994.


Source of Support: Nil

Conflict of Interest: None declared.

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