INTRODUCTION

Juvenile xanthogranuloma (JX) is a rare, non-Langerhans histiocytic proliferative disease, generally seen in childhood [1]. JX in adult is very rare and in some of adult cases, there were reported concurrent hematological malignancies [2–4]. In the present case, a 41-year-old female patient who has disseminated JX lesions with adult onset is presented.

CASE REPORT

41 year old female patient was admitted to our clinic with papules all over her body. Lesions started 3 years ago on her face and they remained stabile until having a traffic accident 1 year ago. After accident and subsequently operation, the lesions began spreading on whole body. In her personal history, there were a surgical operation because of the accident and concurrently diagnosis of diabetes mellitus. In her family history there was nothing important. In dermatological examination, multiple yellowish-pink coloured, some dome-shaped, indurated papules were detected on her head, hairy skin, external auditory canal, pubis and upper torso (Figs 1 – 3). Routine laboratory tests were normal. Histopathological examination of the lesions showed histiocytic infiltration and multinuclear giant cells and actin, desmin, S100 and factor XIIIa stains were found negative whereas CD68 was positive (Figs a href=”#F4″>4a – d). Based on clinical and histopathological findings, patient was diagnosed as JX. There were no pathological findings in ocular and respiratory examinations of the patient. The patient was followed because the lesions has possibility of spontaneous resolution. But, 6 months later, there were no regression in control examination.

Prior to the study, patient gave written consent to the examination and biopsy after having been informed about the procedure.

DISCUSSION

JX is an uncommon non-langerhans histiocytic proliferative disease which %75 of cases were diagnosed in the first year of life. It is rarely seen in adults and the lesions generally seen as solitary and resisted to spontaneous regression [1]. Some of the adult cases with disseminated lesions were associated hematologic malignancy, mostly leukemias [2–4]. Our case is adult onset disseminated JX case without malignancy association.

The etiology of JX is still unknown however, it is suggested that it might be a reactive disorder responding to any traumatic or infectious stimulus [1]. Our case has trauma history and diabetes mellitus and dissemination of the lesions was simultaneously with trauma diagnosis of diabetes mellitus. So, we think that trauma and/or diabetes mellitus may be potential triggering factors for JX.

In many cases, lesions are limited to the skin and benign characterized [1]. Extracutaneous infiltration was reported in %5 of cases. The most common site are eye and lung. Early recognition is important to avoid complications [5]. In our case, there was no pathological findings in physical or radiological examinations that indicates any systemic involvement.

Associations between JX and neurofibromatosis type 1 (NF1), juvenile myelomonocytic leukemia (JML), urticaria pigmentosa, Niemann-Pick disease and diabetes mellitus were reported [6]. Our case has also diabetes mellitus.

Differential diagnosis firstly includes non Langerhans-Langerhans cell histiocytosis. The other differential diagnoses are xanthomas, molluscum contagiosum, neurofibroma, spitz nevus. Diagnosis of JX is done by clinical, histopathological and immunohistochemical examinations [7,8]. In histological examination of JX lesions, characterized Touton cells with ring shaped nucleus, foamy cytoplasma are seen and S100, CD1a stains are negative whereas CD68 stain is positive similarly in our case [9].

The lesions usually regress spontaneously in 3-6 years or sometimes with hyperpigmentation, atrophy or anetoderma. For diagnosis or cosmetic concerns, they could be excised [1]. Our case has multiple lesions, so excision was not suggested.

In conclusion, JX may occur in adult and dermatologist should keep in mind in the patients with yellowish-pink coloured, indurated papules. Trauma and diabetes mellitus may be a triggering factor for dissemination of JX.