2014.1-5a.Comment

                                                                                                 article in PDF
Our Dermatol Online 2014; 5(1): 33
Date of submission:  07.01.2014 / acceptance: 09.01.2014
Conflicts of interest: None
 
PROPOSAL OF EMPLOY OF EXTRACT OF DESMODIUM ADSCENDENS AS ANTI-HISTAMINIC DRUG: TRIALS OF EFFICACY BY REFLECTANCE SPECTROPHOTOMETRY
by

Lorenzo Martini, Roberto Solimé

COMMENT:

Assoc. Prof. Miloš Jeseňák, MD., PhD., MBA

Department of Paediatrics, University Hospital in Martin
Center for Diagnosis and Treatment of Primary Immunodeficiencies
Center for Treatment of Severe Allergic Diseases
Jessenius Faculty of Medicine of Comenius University in Bratislava
Kollarova 2, 036 59 Martin Slovak Republic
E-mail: jesenak@gmail.com 

 
     Complementary and alternative medicine is surviving across the decades and also in the medicine of 21st century. The physicians are meeting different preparations during their praxis and the challenge for them is to find the right way how to navigate the patients in the middle of thousands of preparations and methods. Complementary and alternative medicine is considered to be the therapeutic approaches and methods which are not involved in the standard conventional treatment schema. This medicine should not be alternative to the standard therapy but should be used complementary. Many studies have confirmed that the patients suffering from chronic allergic diseases (respiratory, skin) are very prone to use various methods of alternative medicine [1]. In general these preparations are considered to be safe, but in reality, they can worsen the allergic diseases and can be in conflicts with standardly applied therapy [2]. Therefore it is very necessary to provide the studies such as the study by Martini & Solimé [3] which are able to show the proposed efficacy of the selected modality of alternative therapy along with the confirmation of their safety. Today, many preparations of complementary medicine possess the relevant studies which are able to fulfil the strict criteria of evidence based medicine. Many widely used natural immunomodulators, e.g. beta-glucans, have shown the anti-allergic characteristics [4]. They have also the positive effects on the skin physiology [5]. Another widely studied group of natural preparations and different phytopharmacs. The study of Martini & Solimé [3] objectively showed that the extract of Desmodium adscendens possesses antihistaminic and antiallergic effect on the skin erythema. The plant Desmodium adscendens used for decades in the traditional medicine in many pathological conditions. The current study can support its topical used in the complex management of atopic eczema and other skin diseases which are accompanied with erythema and pruritus. The topical complementary therapy and other modalities are highly required by the desperate eczematic patients [6]. This study enlarges the possibilities of complementary topical therapy of chronic skin diseases in the context of “integrative medicine”, which combines the successes of standard, conventional and complementary therapy. There is an urgent need also to perform the studies with other widely used and recommended preparation for eczema just to create some system in this broad group of natural products.
 
REFERENCES
1. Boneberger S, Rupec RA, Ruzicka T. Complementary therapy for atopic dermatitis and other allergen skin diseases: facts and controversies. Clin Dermatol. 2010;28:57-61.
2. Chang C, Gershwin ME. Integrative medicine in allergy and immunology. Clinic Rev Allerg Immunol. 2013;44:208-28.
3. Martini L, Solimé R. Proposal of employ of extract of Desmodium adscendens as anti-histaminic natural drug: trials of efficacy by reflectance spectrophotometry. Our Dermatol Online. 2014;5:28-31.
4. Jesenak M, Banovcin P, Rennerova Z, Majtan J. β-glucans in the treatment and prevention of allergic diseases. Allergol Immunopathol (Madr) 2012; doi. 10.1016/j.aller.2012.08.008.
5. Majtan J, Kumar P, Koller J, et al. Induction of metalloproteinase 9 secretion from human keratinocytes by pleuran (befa-glucan from Pleurotus ostreatus). Z Naturforsch C. 2009;64:597-600.
6. Soyer OU, Aksoy I, Dallar Y. The use of alternative medicine in children with atopic dermatitis. Allergol Immunopathol (Madrid) 2013;41:275-6.


CONTENT

SERVICES

Other Resources

Our Dermatology Online

Home
Current Issue
All Issues
Instruction for authors
Submit Manuscripts
Ethics in Publishing
For Reviewers
Readers
About
Editors & Publishers 
Statistics
Copyright
Contact Us