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Our Dermatol Online.  2013; 4(Suppl. 2): 437-439
DOI:.  10.7241/ourd.20133.113
Date of submission:  03.05.2013 / acceptance:19.06.2013
Conflicts of interest: None


Khalid Al Aboud1, Daifullah Al Aboud2

1Department of Public Health, King Faisal Hospital, Makkah, Saudi Arabia
2Dermatology Department, Taif University, Taif, Saudi Arabia

Corresponding author:  Dr. Khalid Al Aboud    e-mail:

Cite this article: Al Aboud K, Al Aboud D. Eponyms in the dermatology literature linked to Italy. Our Dermatol Online. 2013; 4(Suppl. 2): 437-439.


Italy is one of the largest European countries. With 60.8 million inhabitants, it is the fifth most populous country in Europe [1]. It has been ranked as the world’s 25th most-developed country and it Quality-of-life Index was ranked in the world’s top ten in 2005. Italy enjoys a very high standard of living and has a high public education level [1]. It ranks as having the world’s 2nd best healthcare system, and the world’s 3rd best healthcare performance. Italy had the 12th highest worldwide life expectancy in 2010 [1]. Many of the important dermatology educational resources and periodicals are based in Italy. In Table I [2-16], we listed selected eponyms in dermatology literature linked to Italy.
Eponyms in the dermatology
literature linked to Italy
Anetoderma of Jadassohn–Pellizzari
netoderma is clinically characterized by localized areas of flaccid or herniated sack-like skin. Currently it is usually classified into two clinical groups: primary anetoderma, which arises from previously normal skin and secondary anetoderma, which occurs at sites of skin diseases such as syphilis, acne, lupus, or varicella. Primary anetoderma can be divided into Schweninger- Buzzi type (no preceding erythema) and Jadassohn-Pellizzari type (preceded by macular erythema or papular urticaria). In addition to Pellizzari’s anetoderma, the Italian dermatologist, Celso Pellizzari (1851-1925), (Fig. 1). Also, discovered several nosologic entities such as colloid pseudomilium.
Figure 1. Celso Pellizzari
Angiokeratoma of Mibelli (also
porokeratosis of Mibelli) [3]
Angiokeratoma of Mibelli and porokeratosis of Mibelli, both are well known skin diseases are named after, Vittorio Mibelli (1860-1910), (Fig. 2), who was an Italian dermatologist born in Portoferraio, Elba.
Figure 2. Vittorio Mibelli
Atrophoderma of Pasini-Pierini [4-7]
Idiopathic atrophoderma of Pasini and Pierini is a rare, disorder of dermal atrophy described by Pasini in 1923 and Pierini & Vivoli in 1936. The typical presentation is an ovoid, mildly depressed, hyperpigmented lesion of the trunk. Though the disorder was first described by an Italian physician, Agostino Pasini (1875-1944) in 1923; it was Luis Pierini, an Argentinean physician who pursued its study among 50 Argentinean cases and definitively defined its clinical and histological features. Canizares in 1957 introduced the disorder to American literature and also named it after its two pioneers. Linear atrophoderma of Moulin (LAM) is a rare dermatologic disorder characterized by a hyperpigmented atrophoderma that consistently follows the lines of Blaschko. This disease
was first referred to as Atrophoderma of Moulin after Dr. Moulin who first reported it in 1992 then was renamed as linear atrophoderma of Moulin. There are many clinical and histologic similarities between LAM, atrophoderma of Pasini and Pierini (APP), and morphea, and whether LAM represents part of a disease spectrum or its own distinct entity is debated.
Gianotti–Crosti syndrome [8,9]
Also known as papular acrodermatitis of childhood. It is a skin rash asoociated with viral
infections. It is named after, Ferdinando Gianotti (1920-1984), who was an Italian physician and Agostino Crosti (1896-1988), who was an Italian dermatologist, and Professor of Dermatology in Milan. Crosti’s syndrome is named, also, after Agostino Crosti.
Golgi apparatus [10]

The Golgi apparatus, also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryoticcells. It was identified in 1897 by Camillo Golgi and named after him in 1898. Camillo Golgi (1843-926), (Fig. 3), was an Italian physician, pathologist, scientist, and Nobel laureate.

Figure 3. Camillo Golgi (1843-926)
Haemophilus ducreyi [11]

It is a gram-negative coccobacillus causing the sexually transmitted disease chancroid, a major cause of genital ulceration in developing countries. It is named for, Agosto Ducrey (1860-1940), (Fig. 4), who was an Italian dermatologist.

Figure 4. Agosto Ducrey
Malpighian layer [12]

The Malpighian layer of the skin is a term that is generally defined as both the stratum basale and stratum spinosum as a unit. It is named for an Italian doctor; Marcello Malpighi (1628-694), (Fig. 5).

Figure 5. Marcello Malpighi
Pasini type of epidermolysis bullosa
The autosomal dominant of dystrophic epidermolysis (DDEB) has been conventionally divided into Pasini and Cockayne-Touraine variants on the basis of the presence or absence of whitish dermal papules, so-called albopapuloid lesions, respectively. But the issue is clouded by the fact that albopapuloid lesions, which are most often seen on the trunk, are probably not specific. In 1928, Pasini described a single family whose EB was distinguished by the presence of numerous white papules that he called ‘albopapuloid’ lesions. Larger series of patients with DDEB were reported by Cockayne (1933) and Touraine (1942).

                Table I. Selected Eponyms in the dermatology literature linked to Italy

1. Italy.Wikipedia® [Internet]. Wikimedia Foundation. [Updated 2 May2013; cited 2 May 2013]. Available from:
2. Roberts NM, Farrell A, Woodrow D, Leibowitch M, Staughton RC: Anetoderma of Jadassohn-Pellizzari. J R Soc Med. 1995;88:599P-600P.
3. Allegra F: The man behind the eponym. Vittorio Mibelli and the tale of „porokeratosis”. Am J Dermatopathol. 1986;8:169-72.
4. Handler MZ, Alshaiji JM, Shiman MI, Elgart GW, Schachner LA: Congenital idiopathic atrophoderma of Pasini and Pierini. Dermatol Online J. 2012;18:4.
5. Tolat S N, Kotkar D, Punamiya C K: Atrophoderma of pasini – pierini. Indian J Dermatol Venereol Leprol. 1993;59:135-7.
6. de Golian E, Echols K, Pearl H, Davis L: Linear Atrophoderma of Moulin: A Distinct Entity? Pediatr Dermatol. 2012;Oct 9.
7. Wongkietkachorn K, Intarasupht J, Srisuttiyakorn C, Aunhachoke K, Nakakes A, Niumpradit N: Linear atrophoderma of moulin: a case report and review of the literature. Case Rep Dermatol. 2013;5:11-4.
8. Sarma N, Sarkar UK, Das MK, Das S: Hemorrhagic Gianotti-Crosti Syndrome in a One and Half Month old Infant: An Extremely Unusual Presentation. Indian J Dermatol. 2013;58:65-7.
9. [No authors listed]: [Agostino Crosti]. G Ital Dermatol Minerva Dermatol. 1966;107:399-412.
10. Dröscher A: Camillo Golgi and the discovery of the Golgi apparatus. Histochem Cell Biol. 1998;109:425-30.
11. Li W, Katz BP, Spinola SM: Haemophilus ducreyi-induced interleukin-10 promotes a mixed M1 and M2 activation program in human macrophages. Infect Immun. 2012;80:4426-34.
12. Battistuzzi PG: [The tubules of Malpighi and the stratum of Malpighi]. Ned Tijdschr Tandheelkd. 2009;116:538.
13. Jonkman MF, Moreno G, Rouan F, Oranje AP, Pulkkinen L, Uitto J: Dominant dystrophic epidermolysis bullosa (Pasini) caused by a novel glycine substitution mutation in the type VII collagen gene (COL7A1). J Invest Dermatol. 1999;112:815-7.
14. Cockayne EA: Inherited Abnormalities of the Skin and its Appendages. London: Oxford Univ. Press, 1933.
15. Touraine MA: Classification des epidermolyses bulleuses. Ann Derm Syph. 1942;8:138-44.
16. Pasini A: Dystrophie cutanee buleuse atrophiante et albo-papuloide. Ann Derm Syphilgr (Paris). 1928;9:1044-66.

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