Jean Christopher Chamcheu, PhD

 

Jean Christopher Chamcheu, PhD – USA                                                            

Department of Dermatology, School of Medicine and Public Health, University of Wisconsin-Madison, 1300 University Ave, MSC 4385, Madison, WI 53706, USA.

Ph: (608) 263-5519

Fax: (608) 263-5223

E-mail: jcchamcheu@dermatology.wisc.edu

Education
PhD in Dermatology & Venereology June 2010
Uppsala University, Medical Faculty, Department of Medical Sciences, Uppsala, Sweden. 
Dissertation entitled:” Disease-causing Keratin Mutations and Cytoskeleton Dysfunction in Human Skin: In vitro Models and new Pharmacologic Strategies for Treating Epidermolytic Genodermatoses”. Advisors: Anders Vahlquist, Hans Törmä and Harshad Navsaria
Master of Science (M.Sc) in Biomedicine June 2004
Linköping University, Faculty of Health Sciences, Linköping, Sweden
Thesis entitled:” Cellular and Molecular Effects of Ambient Air Pollution Particles on Human Blood Platelets: Implications on Cardiovacular, Respiratory and Inflammatory Diseases” Advisors: Profs. Magnus Grenegård & Margaretha Lindroth
Bachelor of Science (B.Sc) in Biochemistry September 2000
University of Dschang, Faculty of Sciences, Department of Biochemistry, Cameroon,
 
Research Interests
Screening and identification of the genetic and molecular basis of human skin diseases and the mechanisms that lead to clinical phenotypes.
Development of in vitro models and tools for treating skin disorders.
Skin tissue engineering, therapeutic applications and solving complex biomedical problems with an ultimate goal to develop novel, biologically valid therapeutic strategies.
 
Work Experience
Postdoc Research Associate: Department of Dermatology, School of Medicine and Public Health,Department of Dermatology, School of Medicine and Public Health,
Visiting Scientist: Centre for Cutaneous Research, ICMS, Queen Mary School of Medicine and Dentistry, London, United Kingdom January-June 2006
Laboratory Instructor: Department of Medical Sciences, Dermatology and Venereology, Uppsala, Sweden, October-2005
Teaching Assistant: Department of Medical Sciences, Dermatology and Venereology, Uppsala, Sweden October-2005 – present
Research Assistant: Department of Medical Sciences, Dermatology and Venereology, Uppsala, Sweden Oct, 2004 – October 2005
Research Assistant: Department of Biomedicine and surgery, Linköping Hospital 2004
Clinical Laboratory Research Assistant: District Hospital / Medical Research Station, Kumba, September 1999 – Oct 2001
 
Membership of scientific Societies
American Chemical Society
Europan Society for Dermatological Research
Swedish Association on University Teachers
Swedish Society for Biochemistry and Molecular Biology
Society for Investigative Dermatology
 
Publications
Chamcheu JC, Navsaria H, Pihl-Lundin I, Liovic M, Vahlquist A, Törmä H (2011). Chemical chaperones protect epidermolysis bullosa simplex keratinocytes from heat stress-induced keratin aggregation: Involvement of heat shock proteins and MAP Kinases. Journal of Investigative Dermatology, 2011 (In press).
Chamcheu JC, Pihl-Lundin I, Eteti MC, Gester T, Virtanen M, Moustakas A, Navsaria H, Vahlquist A, Törmä H. Immortalized keratinocytes derived from epidermolytic ichthyosis patients reproduce the disease phenotype: a useful in vitro model for testing new treatments. British Journal of Dermatology, 2011;Feb; 164(2):263-272.
Chamcheu JC, Virtanen M, Navsaria H, Bowden PE, Vahlquist A, Törmä H. Epidermolysis bullosa simplex due to KRT5 mutations: Mutation-related differences in cellular fragility and the protective effects of trimethylamine N-oxide (TMAO) in cultured primary keratinocytes. British Journal of Dermatology, (2010), 162 (5): 980-989.
Pavez Loriè E, Chamcheu JC, Vahlquist A, Törmä H. Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolising enzymes and retinoid biomarkers in organotypic epidermis. Archives of Dermatological Research, 2009; 301(7):475-85.
Chamcheu JC, Pavez Loriè E, Akgul B, Bannbers E, Virtanen M, Gammon L, Moustakas A, NavsariaH, Vahlquist A and Törmä H. Characterization of immortalized human epidermolysis bullosa simplex (KRT5) cell lines: Trimethylamine N-oxide protects the keratin cytoskeleton against disruptive stress condition. Journal of Dermatological Science, 2009; 53(3):198-206.
Chamcheu JC, Siddiqui IA, Syed DN, Adhami VM, Liovic M, Mukhtar H. Keratin gene mutations in disorders of human skin and its appendages. Arch Biochem Biophys, 2010 Dec 19. [Epub ahead of print]; PMID: 21176769.
Chamcheu JC, Disease-causing Keratin Mutations and Cytoskeleton Dysfunction in Human Skin: In vitro Models and new Pharmacologic Strategies for Treating Epidermolytic Genodermatoses. Society for the Publication of Acta-Dermato-Venereologica (ISSN 1402-2915), Forum for Nord Derm Ven, 2010, 15(4): 120-121.
Chamcheu JC, Disease-causing Keratin Mutations and Cytoskeleton Dysfunction in Human Skin: In vitro Models and new Pharmacologic Strategies for Treating Epidermolytic Genodermatoses. Acta Universitatis Upsaliensis, 2010; ISSN1651-6206; 564: Published thesis.


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