Psoriasis is a chronic, relapsing inflammatory skin disease with silver plaques, Shell transition, and erythematous condition. Psoriasis is a polygenic disease that can occur at any age. Although in more than 75% of patients, the first symptoms are manifested before the age of 40 [1,2]. Furthermore, the association between psoriasis and inflammatory and metabolic disorders have also been reported. Several factors are involved in causing psoriasis such as trauma, infections, lifestyle, such as obesity, smoking and certain medications such as beta-blockers, and lithium, antimalarial drugs [3], nonsteroidal anti-inflammatory drugs, also Corticosteroid dose reduction noted in people who are genetically prone to cause disease [4,5].

From NBUBV In combination with Calcipotriol is also used to treat psoriasis. Studies that have evaluated the combined effect of Calcipotriol and NBUBV have offered varying results [6,7]. In this study, we attempt to evaluate the effectiveness of the cream Daivonex alone and to combine this method with phototherapy with NBUBV and to Choose an appropriate method that can, cause the greatest improvement in shortest time And can be more effective and safe therapy for the treatment of these patients.

All the patients referred to the dermatology department of the sina hospital from October 2013 to March 2014 witch had been diagnosed with psoriasis, we chose the study cases totally random. To determine the sample size we used Rim Jh and colleagues study. In this study, the changes in the intensity of the thickness (induration) was considered as the primary outcome 94 individuals.

During the process of collecting samples from individuals who have less than 10% BSA or had limited psoriasis, if other criteria were matched they referred to responsible resident to be reviewed. The patients were randomly divided into 2 groups of 47, with no age limit. Anthropometric characteristics such as height and weight were determined for each individual. Duration of illness in patients was determined and patients were categorized according to the type of medication or unit weight in mg doses and duration of drug use. And each group was been treated with one of the 2 therapy methods as follows: All the patients underwent routine tests before starting treatment. Those in the treatment group of Daivonex.

Cream used 5.0 mg every 12 hours to the surface of the body used the palm of a hand to measure it. Patients used creams with Behestan Behdasht (under license Leo pharma, Denmark) brand. Those in the treatment group witch treated with cream Daivonex with NBUVB 2 times a week using Dermapal 800 Davlin machine made in United States of America with a primary energy of 2.0 joules per square centimeter were under phototherapy. In the next sessions 1/0 joules per square centimeter on the amount of energy was added by the system. These patients were similar to the previous group witch were using cream with the difference that in the days of phototherapy, the cream used after PHOTOTHERAPY. All patients at baseline and 4, 8 and 12 weeks after starting treatment were visited and the improvement of erythema, scaling, thickening (induration) lesion (no = 0, less than 30% = low, 30 -60% = average, over 60% = high) and the response to treatment was assessed and defined in to grades according to the following Table 1.

For 12 weeks, according to previous studies, it was enough for patients and patients relapse after completion of the study were not examined.

To eliminate bias in the study some inclusion criteria were determined.

Inclusion criteria for this study include:

Having mild psoriasis

Exclusion criteria:

Failure to comply with any of the criteria for inclusion

This study is registered with registration number IRCT138903294207N1 in database of registered clinical trials.

According to the results of our study subjects in the two groups in terms of sex, age, weight, height, history of diabetes, duration of psoriasis, the plight and size differences were not significant The mean improvement in erythema and crust investment and improve in lesion thickness overall recovery of lesion in the fourth week, eighth and twelfth after starting treatment in patients who were treated with creams and phototherapy were Significantly higher than the group that used the cream alone. The results of our study show that the use of cream in combination with phototherapy Daivonex Phototherapy with faster and more recovery at a time can be used to provide better results [8]. It can be concluded that patients can improve the speed of treatment side effects, including cumulative effects of phototherapy dose reduction That the matter should be further investigated in other comparative studies. Similar to Noborio et al study in 2006 concluded that the therapeutic effects of Calcipotriol is higher than other drugs in combination with phototherapy [9]. The results of our study showed that Calcipotriol in combination with phototherapy increase the speed and the amount of improvement.

As a study done by Jong-Hyun Rim et al [10] in our study, the use of Calcipotriol cream in combination with phototherapy with an appropriate treatment was introduced to accelerate and enhance recovery.

As a study done by Takahashi et al [6], the results of our study showed that the combination of Calcipotriol Ointment with NB-UVB twice a week, compared to other treatments, the rate and extent of psoriasis of lesion can be further improved.

As a study done by Rogalski et al [7] as well as a study done by Roussaki-Schulze et al [11], in our study group Calcipotriol alone received less improvement than the other groups showed. This could indicate an increased therapeutic effect in combination with other treatments is Calcipotriol, or excimer laser, or narrowband ultraviolet radiation.

Unlike our study Karakawa et al as “the period of remission treated with narrowband ultraviolet B in psoriasis vulgaris” did And retrospectively studied the factors that influence the duration of remission after photo chemotherapy so we compared [8]. The two methods together, to achieve a therapeutic effect that is the most efficient and lowest paid.

The results of our study show that the use of cream Daivonex in combination with phototherapy By creating more and faster recovery time can be as a treatment that can be used to provide better results So that in the group treated with cream Daivonex, at the end of the study 30.2% of patients achieved complete remission, while the combination of cream and ultra violet Daivonex narrowband cure rate was 73.8 percent.