MyLibraryZotero17Mofarrah, RaminMofarrah, RaminaAmiri, Kousar JahaniOur Dermatology OnlineOur Dermatology OnlineOur Dermatol Online59-61111120202020-1-22081939010.7241/ourd.20201.15A number of beta-adrenoceptor blocking drugs have been reported to be upon the most common causative agents for drug-induced psoriatic lesions. Apparently this adverse reaction appears after several months of continuous therapy. In our case psoriasis eruption is associated with bisoprolol (B1-blocker) therapy in a man without previous skin lesions and history of psoriasis. The biopsy demonstrated psoriasiform dermatitis with spongiosis and parakeratosis. The pathogenic mechanisms to be discussed are the pharmacological effects on the epidermal beta-adrenergic adenylate cyclase-cyclic AMP system and on the excessive release of lysosomal enzymes.DOI.org (Crossref)enhttp://www.odermatol.com/issue-in-html/2020-1-15-psoriasis/D:\OurDermatolOnline\numer 2020 1\pdf\15.Beta-MofarrahR.pdf2020-01-01 11:41:00