<!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" "journalpublishing.dtd">
<article article-type="letter" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML">
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">Our Dermatol Online</journal-id>
<journal-title>Our Dermatol Online</journal-title>
<issn pub-type="epub">2081-9390</issn>
<publisher>
<publisher-name>Our Dermatology Online</publisher-name>
<publisher-loc>Poland</publisher-loc>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="publisher-id">OURD-8-108</article-id>
<article-id pub-id-type="doi">10.7241/ourd.20171.31</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Letter to the Editor</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>A distinct cutaneous leishmaniasis lesion on the tip of the patient&#x2019;s nose: A visual warning for European colleagues</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Tamer</surname>
<given-names>Funda</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="corresp" rid="cor1"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Yuksel</surname>
<given-names>Mehmet Eren</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label><italic>Department of Dermatology, Medical Park Hospital, Ankara, Turkey</italic></aff>
<aff id="aff2"><label>2</label><italic>Devrek State Hospital, Department of General Surgery, Zonguldak, Turkey</italic></aff>
<author-notes>
<corresp id="cor1">
<bold>Corresponding author:</bold> Dr. Funda Tamer, E-mail: <email xlink:href="fundatmr@yahoo.com">fundatmr@yahoo.com</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub">
<year>2017</year>
</pub-date>
<volume>8</volume>
<issue>1</issue>
<fpage>108</fpage>
<lpage>109</lpage>
<history>
<date date-type="received"><day>27</day><month>04</month><year>2016</year></date>
<date date-type="accepted"><day>11</day><month>06</month><year>2016</year></date>
</history>
<permissions>
<copyright-statement>Copyright: &#x000a9; Our Dermatol Online 1</copyright-statement>
<copyright-year>2017</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p>
</license>
</permissions>
</article-meta>
</front>
<body>
<sec id="sec1-1">
<title/>
<p>Sir,</p>
<p>An 18-year-old Caucasian male presented with a six-month history of non-healing wound on his nose. The patient admitted that the lesion started as a small erythematous papule and it increased in size gradually. Thereafter, the lesion became ulcerated. It was painless, however bleeding occured when the patient scratched the lesion on the tip of his nose. The past medical history was unremarkable. The patient was living in a rural area of eastern Anatolia in Turkey. The physical examination revealed an erythematous, indurated, crusted plaque on the tip of the nose (Figs. <xref ref-type="fig" rid="F1">1</xref> and <xref ref-type="fig" rid="F2">2</xref>). A skin biopsy was performed to reach a definitive diagnosis. The histopathological examination revealed cutaneous leishmaniasis. The patient was treated with intralesional meglumine antimoniate three times a week and cryotherapy every two weeks untill the lesion was completely healed.</p>
<fig id="F1">
<label>Figure 1</label>
<caption>
<p>Cutaneous leishmaniasis: An erythematous, indurated, crusted plaque on the tip of the patient&#x2019;s nose.</p>
</caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="OURD-8-108-g001.tif"/>
</fig>
<fig id="F2">
<label>Figure 2</label>
<caption>
<p>The right lateral view of the cutaneous leishmaniasis lesion on the patient&#x2019;s nose.</p>
</caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="OURD-8-108-g002.tif"/>
</fig>
<p>Cutaneous leishmaniasis is a parasitic disease which clinically presents with erythema, papule, nodule and ulcerative skin lesions. The causative agent of cutaneous leishmaniasis is the leishmania parasite which has several species. The leishmania parasites are spread by the bite of infected sandflies. Therefore, the leishmania lesions usually occur on the site of the sandfly bites including face, hands and feet [<xref ref-type="bibr" rid="ref1">1</xref>]. It has been suggested that approximately 1.71 billion people are at risk for cutaneous leishmaniasis in the world [<xref ref-type="bibr" rid="ref2">2</xref>]. The presence of sandflies, climate factors like temperature, unawareness of the disease, poor personal protection, poor housing and environmental conditions are the factors which affect the incidence and distribution of cutaneous leishmaniasis [<xref ref-type="bibr" rid="ref2">2</xref>]. Cutaneous leishmaniasis occurs worldwide, however, most cases ocur in Afghanistan, Algeria, Brazil, Pakistan, Peru, Saudi Arabia, and Syria [<xref ref-type="bibr" rid="ref1">1</xref>].</p>
<p>Cutaneous leishmaniasis is endemic in Syria and increased incidence of the disease has been reported between 1997 and 2011 [<xref ref-type="bibr" rid="ref3">3</xref>]. Recently, civil war in Syria led massive displacement of people. Therefore, the number of cutaneous leishmaniasis cases increased significantly in neighbouring countries like Turkey, Jordan and Lebanon [<xref ref-type="bibr" rid="ref3">3</xref>]. Alawieh et al. reported that 96.6&#x0025; of the all new cases in Lebanon in 2013 occured among Syrian refugees [<xref ref-type="bibr" rid="ref4">4</xref>].</p>
<p>Cutaneous leishmaniasis is endemic in southeastern Anatolia, eastern Anatolia and eastern mediterranean regions of Turkey. Inci et al. investigated the effect of Syrian war on prevalence of cutaneous leishmaniasis in southeastern Anatolia. They evaluated 110 patients who were diagnosed with cutaneous leishmaniasis between 2011 and 2014. 69&#x0025; of the patients were Syrian refugees. Inci et al. reported that there was a relationship between increased incidence of cutaneous leishmaniasis and increased number of Syrian refugees from highly endemic areas [<xref ref-type="bibr" rid="ref5">5</xref>].</p>
<p>Moreover, refugees from countries where cutaneous leishmaniasis is endemic may spread the infection to non-endemic regions including European countries. For this reason, health care providers in Europe should be aware of the diagnosis and management of cutaneous leishmaniasis. Therefore, we would like to share a case of cutaneous leishmaniasis with distinct clinical features with our European colleagues.</p>
</sec>
</body>
<back>
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<fn-group>
<fn fn-type="supported-by">
<p><bold>Source of Support:</bold> Nil</p>
</fn>
<fn fn-type="conflict">
<p><bold>Conflict of Interest:</bold> None declared.</p>
</fn>
</fn-group>
</back>
</article>