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Eccrine porocarcinoma: A rare adnexal skin cancer
Mamadou Diouldé 1 Kante
1,2, Khadim Diop3, Abdoulaye Sadio Diallo2,4
1Department of Dermatology, Donka National Hospital, Conakry, Guinea, 2Faculty of Health Sciences and Technology, Gamal Abdel Nasser University of Conakry, Conakry, Guinea, 3Department of Dermatology, Aristide LeDantec Hospital, Dakar, Senegal, 4Department of Pathological Anatomy and Cytology, Donka National Hospital, Conakry, Guinea
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Sir,
Eccrine porocarcinoma is a malignant skin tumor with a poor prognosis derived from the intraepidermal ductal part of the sweat gland. It is a rare entity representing less than 0.01% of all skin cancers. It arises from a pre-existing eccrine poroma or develops de novo [1,2]. Its clinical presentation is not highly specific, and the histological diagnosis is sometimes difficult. Herein, we report a case of eccrine porocarcinoma remarkable for its rarity, topography, the absence of metastases, and its clinical presentation highly similar to squamous cell carcinoma [2,3].
This was a 72-year-old patient seen in dermatology consultation for an ulcerated tumoral lesion of the left buttock evolving for the previous ten months. A physical examination found an ulcero-budding tumor on the left buttock, rounded in shape, with an infiltrated base measuring 2.5 cm in diameter, bleeding on contact and necrotic in places (Fig. 1a). The rest of the physical examination was normal. There was no satellite adenopathy. This clinical appearance was suggestive of squamous cell carcinoma. Histology found a poorly limited infiltrating carcinomatous proliferation involving the entire height of the dermis. It was composed of cells with cytonuclear atypia with rare mitoses organized into guts, granuliform tubes, sometimes cribriform, and necrotic cysts compatible with porocarcinoma (Fig. 1b). An extension assessment was normal. Tumor excision was performed after a multidisciplinary consultation meeting (RCP). The evolution was favorable without recurrence after twelve months of follow-up.
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Figure 1: a) The ulcero-budding lesion on the left buttock. b) The infiltrating carcinomatous proliferation affecting the entire height of the dermis (H&E; 200x). |
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The examination of the patient was conducted according to the principles of the Declaration of Helsinki.
The authors certify that they have obtained all appropriate patient consent forms, in which the patients gave their consent for images and other clinical information to be included in the journal. The patients understand that their names and initials will not be published and due effort will be made to conceal their identity, but that anonymity cannot be guaranteed.
REFERENCES
1.Kottler D, Rivet J, Hickman G, Comte C, Duron JB, Basset-Seguin N, et al. [Eccrine porocarcinoma with Bowenoid changes:A challenging diagnosis of adnexal neoplasm]. Ann Pathol. 2014;34:378 83.
2.Skowron F, Poulhalon N, Balme B, Touzet S, Thomas L. [Primary eccrine porocarcinoma:A clinicopathological study of 50 cases]. Ann Dermatol Vénéréol. 2014;141:258 64.
3.Rafiei R, Eftekhari H, Daryakar A, Nickhah N, Rafiee B. Eccrine porocarcinoma:A case report and brief review of the literature. Our Dermatol Online. 2016;7:391-3.
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