Patologie cutanată asociată infec?iei COVID-19 în popula?ia pediatrică (Manifestări cutanatela copiii infecta?i cu COVID-19)

First Page (Prima pagina)

ALGORITMUL de TESTARE

1. SARS-CoV-2 reverse transcriptase polymerase chain reaction (RT-PCR).

2. Testare imunologică: anticorpii COVID-19 IgM, IgG, IgA.

3. Analize curente de laborator, probele inflamatorii, testele de coagulare, markerii autoimuni.

STRUCTURA SARS CoV-2

Coronavirusurile (CoVs) sunt virusuri de tip ARN, nesegmentate, monocatenare, anvelopate, care apar?in familiei Coronaviridae, fiind prezente la mamifere ?i oameni [1]. Majoritatea cazurilor raportate în ultimele decenii au fost de tip forme clinice u?oare, 2 epidemii au fost severe: SARS-CoV ?i Middle East Respiratory Syndrome CoV (MERS-CoV, cu o rată cumulativă de deces variind între 10% ?i respectiv 37% [1,2]. Pe baza secven?ierii genetice OMS a stabilit că virusul SARS-CoV-2 are 80% similitudine cu SARS-CoV ?i 50% cu MERS-Co-V, ambele cu origine la lilieci [3]. Transmiterea virală se face de la om la om, prin contact direct sau pe cale respiratorie; transmiterea fecal-orală este posibilă, iar infec?ia gravidelor determină infec?ii fetale sau neonatale [3-5]. RO (reproductive number) a variat mult, atingând ?i valori de 2,24-3,58, astfel un individ bolnav poate infecta 2-3 persoane [5,6]. Virionul Sars-CoV-2 are dimensiuni mici, de 50-200nm ?i con?ine 4 proteine structurale: proteina S (spike protein), proteina de la nivelul anvelopei E, proteina de membrană M ?i nucleocapsidul N [5].

Keywords

  • SARS CoV-2; Proteina S; RT-PCR; urticariene; erup?ie monomorfică; Exantem maculo-papular; virusului HHV6; COVID-19; 

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