Interdigital webspace xanthomas

Mrinal Gupta

Consultant Dermatologist, Treatwell Skin Centre, Jammu, India

Corresponding author: Dr. Mrinal Gupta

Submission: 01.03.2020; Acceptance: 06.04.2020

DOI: 10.7241/ourd.2020e.54

Cite this article: Gupta M. Interdigital webspace xanthomas. Our Dermatol Online. 2020;11(e):e54.1

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© Our Dermatology Online 2020. No commercial re-use. See rights and permissions. Published by Our Dermatology Online.

A 21-year-old male presented, born to consanguineous parents, with asymptomatic yellowish lesions in the hands, elbows and knees since 4 years of age. His younger brother also had similar lesions. Physical examination revealed multiple flat to slightly raised yellow plaques with corrugated surface in the web spaces (Figs. 1a and 1b).

Figure 1: (a and b) Inter digital webspace xanthomas over all webspaces.                 

The laboratory investigations revealed serum cholesterol was 623 mg/dl (normal 140-250 mg) and low density lipoprotein was 436 mg/dl (normal 50-190 mg/dl) with normal triglyceride and HDL levels. These values were suggestive of type II hypercholesterolemia (familial homozygous). Skin biopsy from webspace confirmed the diagnosis of cutaneous xanthoma.

Xanthomas are localized infiltrates of lipid containing foamy macrophages which can indicate an underlying systemic disturbance in lipoprotein metabolism. There are four clinical types of xanthomas; tendinous, planar, tuberous and eruptive. Interdigital xanthomas are rare but almost certainly diagnostic of familial type II hypercholesterolemia.


The examination of the patient was conducted according to the Declaration of Helsinki principles.

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.


Source of Support: Nil.

Conflict of Interest: None declared.

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