EPONYMS IN THE LITERATURE OF CUTANEOUS LYMPHOMAS

Lymphoma is a cancer that starts in cells called lymphocytes, which are part of the body’s immune system. In most lymphomas and leukemias, cutaneous involvement occurs through hematogenous dissemination. One can see several eponyms in cutaneous lymphomas. However, some of them are no longer used in the current nomenclature. For example, In the World Health Organization (WHO) and European Organization for Research and Treatment of Cancer (EORTC) classification of cutaneous lymphomas, WoringerKolopp disease (WKD) is classified as a relatively indolent variant of mycosis fungoides (MF), whereas Ketron-Goodman disease (KGD), which is not classified yet, is generally considered an aggressive lymphoma with bad prognosis similar to the aggressive CD8-positive cutaneous T-cell lymphoma, the cutaneous γ/δ-positive T-cell lymphoma and the tumor stage of MF [1]. In Table I [1-24], we listed selected eponyms in dermatology literature linked to cutaneous lymphomas. EPONYMS IN THE LITERATURE OF CUTANEOUS LYMPHOMAS

Lymphoma is a cancer that starts in cells called lymphocytes, which are part of the body's immune system.In most lymphomas and leukemias, cutaneous involvement occurs through hematogenous dissemination.One can see several eponyms in cutaneous lymphomas.However, some of them are no longer used in the current nomenclature.For example, In the World Health Organization (WHO) and European Organization for Research and Treatment of Cancer (EORTC) classification of cutaneous lymphomas, Woringer-Kolopp disease (WKD) is classified as a relatively indolent variant of mycosis fungoides (MF), whereas Ketron-Goodman disease (KGD), which is not classified yet, is generally considered an aggressive lymphoma with bad prognosis similar to the aggressive CD8-positive cutaneous T-cell lymphoma, the cutaneous γ/δ-positive T-cell lymphoma and the tumor stage of MF [1].In Table I [1-24], we listed selected eponyms in dermatology literature linked to cutaneous lymphomas.

Remarks
Burkitt's lymphoma [1,2] Burkitt lymphoma is an aggressive non-Hodgkin lymphoma which can be classified into endemic, sporadic, and immunodeficiency variants.Although each variant frequently involves extranodal sites, cutaneous involvement with Burkitt lymphoma is very rare.This lymphoma is named after, Denis Parsons Burkitt (Fig. 1), British surgeon , who first described the disease in 1956 while working in equatorial Africa.

Remarks
Crosti lymphoma [3,4] In 1951, Crosti reported on seven patients with ‚reticulo-histiocytoma of the back' who presented with figurate erythematous plaques and nodules on the back or lateral trunk.Reticulohistiocytoma of the back was later classified as a primary cutaneous follicle center lymphoma (PCFCL).It is named after, Agostino Crosti, (1896-1988), an Italian dermatologist, and Professor of Dermatology in Milan.Crosti's syndrome and Gianotti-Crosti syndrome are named after him.
Dutcher bodies [5][6][7][8][9] Dutcher bodies are PAS-positive, diastase-resistant nuclear pseudoinclusions of eosinophilic cytoplasm found in plasma cells described by Dutcher and Fahey in Waldenstrom macroglobulinemia.Dutcher bodies are a feature of clinically indolent, mucosa-associated lymphoid tissue (MALT) lymphomas.There are no essential differences between Dutcher bodies, single or multiple Russell bodies, and the inclusions of Mott cells.They are all aspects of the same phenomenon, representing spherical cytoplasmic inclusions that are either clearly within the cytoplasm or are overlying the nucleus or invaginated into it.Russell bodies, is named after William Russell (1852-1940) (Fig. 2), Scottish pathologist and physician.Mott cell is named after Mott, who described it in 1905.
Dutcher bodies may rarely occur in a benign reactive condition, such as synovitis.While Dutcher bodies may be a clue to the presence of low-grade lymphoma, they are not a definitive feature, particularly in unusual contexts.

Remarks
Lennert lymphoma [19,20] Lennert lymphoma (LL), or the lymphoepithelioid variant of peripheral T-cell lymphoma, is an uncommon entity with rarely seen or reported presentations in the skin.
It was first characterized in 1952 by Karl Lennert (1921-2012) (Fig. 6), who was an eminent German physician and pathologist Pautrier microabscesses [21] An intraepidermal collections of malignant lymphocytes, seen in cutaneous cell lymphoma.It is named after Lucien-Marie Pautrier, although he did not first describe them.
Lucien-Marie Pautrier (1876-1959) (Fig. 7), was a French dermatologist, who headed a leading department at the medical school of Strasbourg.
Richter syndrome [22] Richter syndrome (RS) is large-cell transformation of chronic lymphocytic leukemia (CLL).It commonly involves lymph nodes and bone marrow, but may rarely manifest in skin.Certain triggering factors, such as Epstein-Barr virus infection and p53 overexpression, have been implicated in the pathogenesis of RS.It is named for the American pathologist Maurice Nathaniel Richter (Fig. 8), born in 1897.
Sézary syndrome or Sézary disease [23] In a series of papers from 1938 to 1949, Albert Sézary (1880-1956) (Fig. 9), a French dermatologist and syphilologist, described erythroderma with cellules monstrueuses (monster cells) in the skin and blood, which is now known as Sézary syndrome or Sézary disease.