%0 Journal Article
%T Alternative topical therapy for post-Scabietic Mastocytoid nodules using pimecrolimus cream 1%
%V 10
%N 4
%P 341-343
%U http://www.odermatol.com/issue-in-html/2019-4-5-mastocytoid/
%X Background: most recent review of the post-scabietic nodules clinical and histopathological features showed that the mast cells are the predominant cells in 63.63% either alone or admixed with eosinophils. Pimecrolimus cream 1% stabilizes the cell membranes and inhibits the release of histamine from mast cells and basophils and reduces the activation of eosinophils. Objective: to evaluate an alternative topical treatment of the post-scabietic nodules according to the histopathological findings. Patients and methods: Thirty-four patients with post-scabietic nodules were treated with pimecrolimus cream 1% applied to the lesions twice daily for one month. Results: The response after 4 weeks of continuous therapy showed that: A- Seventeen patients (50%) showed a complete response (complete disappearance of itching and the nodules at the end of the treatment period); B-Nine patients (26.47%) showed a partial response (partial reduction in the size and number of the nodules with reduction of itching); C- Eight patients (23.52%) showed no response to therapy (no changes in the size and number of the nodules and severity of itching) Conclusion: Pimecrolimus cream 1% is an alternative regimen of therapy for the post-scabietic nodules acting through its pharmacological action in the suppression of the inflammatory mediators in the post-scabietic nodules.
%G en
%J Our Dermatology Online
%A Sharquie, Khalifa E.
%A Shanshal, Mohammed M.
%D 2019-10-03