TY - JOUR TI - Dermatofibrosarcoma protuberans (Report of 49 cases) AU - Frikha, Fatma AU - Mseddi, Madiha AU - Bahloul, Emna T2 - Our Dermatology Online AB - Background: retrospective study to elucidate the epidemio-clinical and pathological characteristics, management and evolutional aspects of DFS with comparison with the data of the literature. Procedure: a thirty seven-year study of all cases of DFS. Results: Forty-nine cases of DFS (22 males and 27 females) were diagnosed. Mean age at diagnosis was 48.2 years. The tumor appeared before the age of 15 years in five patients (10%). This was a recurrence in 12% of cases. Five patients reported a history of trauma. The average delay before consultation was 5.6 years. A solitary nodule was the predominant clinical aspect of DFS (59.2%). Mean size was 4.7 cm. The tumor was mainly located on the trunk. The diagnosis of dermatofibrosarcoma protuberans was histologically confirmed in all cases. Immunohistochemical study was achieved in 34 cases and showed positive staining for CD34. The treatment consisted of large surgical excision in all patients. Four patients had revision surgery because of tumor margins. Eight cases (17.4%) presented a local recurrence after a mean delay of 12.5 months. Conclusion: DFS is a low-malignancy potential skin tumor. Treatment of choice is surgery. The main risk is tumor relapse. A long follow-up is then very important to detect it. DA - 2020/01/02/ PY - 2020 DO - 10.7241/ourd.20201.5 DP - DOI.org (Crossref) VL - 11 IS - 1 SP - 25 EP - 31 J2 - Our Dermatol Online LA - fr SN - 20819390 UR - http://www.odermatol.com/issue-in-html/2020-1-5-dermatofibrosarcoma/ Y2 - 2020/01/01/11:13:43 ER -