Sir,

Melanoma is the most dangerous type of skin cancer; it develops from the melanin-producing cells known as melanocytes [1].

Australia and New Zealand have the highest rates of melanoma in the world [2]. High rates also occur in Northern Europe and North America, while it is less common in Asia, Africa, and Latin America [2].

In the United States, melanoma occurs about 1.6 times more often in men than women [3].

Melanoma has become more common since the 1960s in areas mostly populated by people of European descent [2,4].

There are several steps that drive to the real and proclaimed malign skin tumor, and they are the following:

Melanoma Staging:

Stage 0 or Melanoma In Situ

Stage I Melanoma (localized tumor)…

Stage II Melanoma (localized tumor)…

Stage III Melanoma (regional spread)…

Stage IV Melanoma (metastasis beyond regional lymph nodes)…

Brain Metastases.

Breslow Depth and Clark Level.

When melanoma is Stage 0, sometimes referred to as ‘melanoma in situ’, cancer cells have breached only the epidermis (the very outer layer of the skin). Stage 0 melanoma is contained completely in this layer and has not yet moved into the deeper layers of skin. It is considered local melanoma (this group also includes Stage I and Stage II melanoma).

Melanoma staging is based on the American Joint Committee on Cancer (AJCC) staging system. The system assigns a stage based on tumor-node-metastasis (TNM) scores as well as additional prognostic factors. The goal is that melanomas of the same stage will have similar characteristics, treatment options, and outcomes. Learn more about melanoma staging.

Stage 0 melanoma is removed surgically, with minimal but clear margins. This is sometimes called an excision. Wide local excision, a minor surgery, usually cures local melanoma. Learn more about melanoma treatments.

Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click.

After being treated for Stage 0 melanoma, you should conduct regular self-exams of your skin and lymph nodes and have an annual, full-body skin exam performed by a trained dermatologist for the rest of your life. Imaging tests may be ordered as needed to monitor for recurrence.

In stage 0 melanoma, the malignant tumor is still confined to the top layer of the skin, the epidermis, which means that the cancer cells are only found in the outer layer of the skin and have not grown into the second layer of the skin, called the dermis. Stage 0 melanoma is not considered invasive melanoma; the other stages (I, II, III and IV) are invasive. In stage 0 melanoma, there is no evidence that the cancer has spread to lymph nodes or distant sites (metastasis). Stage 0 is local melanoma, meaning it has not spread beyond the primary tumor.

Because of this fact the authors have decided to approach the problem by a dermal cosmeticological treatment, and this is fully legal and not prohibited.

Authors, insofar, decided to intervene to treat these first spots of melanin and try to cancel thanks to natural remedies, idest Fig’s milk from Crotone (Calabria) collected only during summer and grape juice, but only the grapes belonging to the Est Est Est wine from Montefiascone(IT).

These natural ingredients are recomended both for their restoring performance but even because represent excellent sunscreen agents (UVA,UVB, UVC and gammarays).

Fig milk, also known as fig lattice, is a milky substance found inside fig plants (Ficus carica) [5]. This substance has been used traditionally in various dermatological treatments. Here are some of the dermatological properties of fig milk.

Exfoliating properties: Fig milk contains proteolytic enzymes, such as ficin, which help exfoliate the skin, removing dead cells and promoting cell renewal.

Antibacterial and Antimicrobial Properties: Fig latex has demonstrated antibacterial and antimicrobial properties, which can help fight skin infections caused by bacteria and other microorganisms.

Anti-inflammatory properties: Fig milk contains compounds with anti-inflammatory effects, which can help reduce inflammation and redness associated with various skin conditions, such as acne and dermatitis.

Treatment of Warts: Traditionally, fig milk has been used to treat warts. Topical application of latex can help dry warts and promote their removal.

Emollient and Moisturizing Properties: Some components of fig milk can have an emollient and hydrating effect on the skin, helping to keep the skin soft and hydrated.

Antioxidant Properties: Fig milk contains antioxidant compounds that can protect the skin from damage caused by free radicals, helping to prevent premature skin aging [5].

As far as Est Est Est grape juice is concerned, some Researchers [6] stressed the high presence of procyanidines, polymeric phenols and especially glutathione.

Other Researchers on the other hand asserted that glutathion is one of the most beneficial agents to skin bleaching [7].

They referred that:

Glutathione is present intracellularly in its reduced form and plays an important role in various physiological functions. Its skin-lightening effects result from direct as well as indirect inhibition of the tyrosinase enzyme and switching from eumelanin to phaeomelanin production. It is available in oral, parenteral and topical forms. Although the use of intravenous glutathione injections is popular, there is no evidence to prove its efficacy.

Moreover, glutathione which is present in highest percentages in Procanico, the best grape variety of Montefiascone wine, helps to regenerate the production of vit C and E and vit C is wellknown as one of the best skin whitening, agent better than hydroquinone.

Authors have therefore created a transparent microemulsion (η = 101mP) containing fig’s milk (2%) and Procanico (Trebbiano toscano) wine pasteuriseed must.

This cosmetic should be welcome to treat the stage 0 of cutaneous melanoma and avoid that step 0 could transform in steps I,II or III.

The employ of these two natural and sustainable ingredients allow the impediment of the transformation of step 0 melanoma at its very beginning to I, II or III step and moreover is advisable as a strong natural and harmless sun protecting factors.