A case of bullous pyoderma gangrenosum with endometrial adenocarcinoma

Asmae Abdelmouttalib, Najoua Ammar, Mariame Meziane, Nadia Ismaili, Leila Benzekri, Karima Senouci

Dermatology and Venereology Department, Mohamed V University in Rabat, Morocco

Corresponding author: Asmae Abdelmouttalib, MD, E-mail: abdelmouttalibasmae@gmail.com

How to cite this article: Abdelmouttalib A, Ammar N, Meziane M, Ismaili N, Benzekri L, Senouci K. A case of bullous pyoderma gangrenosum with endometrial adenocarcinoma. Our Dermatol Online. 2022;13(4):455-456.
Submission: 09.02.2021; Acceptance: 06.05.2021
DOI: 10.7241/ourd.20224.25

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© Our Dermatology Online 2022. No commercial re-use. See rights and permissions. Published by Our Dermatology Online.

Pyoderma gangrenosum (PG) is a reactive non-infectious inflammatory dermatosis falling under the spectrum of neutrophilic dermatoses. PG is generally classified into four types: ulcerative, pustular, bullous, and vegetative. Among them, bullous PG is known to be a rare type [1]. Herein, we report a case of bullous PG in a seventy-year-old female with a medical history significant for endometrial adenocarcinoma diagnosed five years previously with total hysterectomy and bilateral adnexectomy. Several years later, the patient presented a strangulated eventration treated with musculo-aponeurotic suture. Afterward, she presented purulent and hemorrhagic blisters on the abdominal wall. They were quickly progressive, painful, and necrotic with ragged, undermined edges and violaceous/erythematous borders. An abdominopelvic CT scan showed a large collection in the anterior abdominal wall without intraabdominal extension. Initially, the lesions were considered secondary to superinfection of the abdominal wall and were treated with antibiotics, drainage, and necrosectomy. As the lesions failed to improve, the patient was transferred to the dermatology department and a skin biopsy was performed, confirming the diagnosis of pyoderma gangrenosum (Fig. 1). Although systemic corticosteroids were administered at a dose of 1 mg/kg/day with the lesions starting to heal (Fig. 2), the patient died in less than two months. PG may precede, coexist, or follow diverse systemic diseases. The bullous variety is usually associated with hematologic disorders and is considered a predictor of hematological malignancies, such as acute or chronic myeloid leukemia that indicates characteristic pathophysiology specific to bullous PG. Despite being a well-recognized condition, PG is often diagnosed not early enough. Such a diagnosis should be actively considered when assessing ulcers, as prompt treatment may prevent the complications of prolonged systemic therapy, delayed wound healing, and scarring.

Figure 1: Post-drainage erosive and necrotic lesions with ragged, undermined edges and violaceous/erythematous borders.
Figure 2: The lesions starting to heal after four weeks of systemic corticosteroids.


The examination of the patient was conducted according to the principles of the Declaration of Helsinki.

The authors certify that they have obtained all appropriate patient consent forms, in which the patients gave their consent for images and other clinical information to be included in the journal. The patients understand that their names and initials will not be published and due effort will be made to conceal their identity, but that anonymity cannot be guaranteed.


1. Takenoshita H, Yamamoto T. Bullous pyoderma gangrenosum in patients with ulcerative colitis and multiple myeloma. Our Dermatol Online. 2014;5:310-1.


Source of Support: Nil,

Conflict of Interest: The authors have no conflict of interest to declare.


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