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Bazouti S, Zerrouki N, Dikhaye S, Zizi N. Acrokeratosis verruciformis of Hopf. Our Dermatol Online. 2019;10(1):93-93.


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Acrokeratosis verruciformis of Hopf

Sabah Bazouti1, Nassiba Zerrouki1, Siham Dikhaye12, Nada Zizi12

1Department of Dermatology, Mohammed VI University Hospital of Oujda, Medical School of Oujda, Mohammed the First, University of Oujda, Oujda, Morocco, 2Epidemiology Laboratory of Research and Public Health, Oujda, Morocco

Corresponding author: Dr. Sabah Bazouti, E-mail:

Submission: 16.06.2018; Acceptance: 29.07.2018

DOI: 10.7241/ourd.20191.27

A 30-year-old female presented with multiple nodules, grouped, hyperkeratotic, brownish and malodorous on his feet (Fig. 1), which had been present for more than 3 years. Histopathological examination showed classical feature of “church spires” appearance without dyskeratosis (Fig. 2). Acrokeratosis Verruciformis of Hopf is a rare autosomal dominant genodermatosis. It usually develops during early childhood affecting both sexes equally. Typically, the lesions are warty to convex, brownish to skin-colored papules on the dorsa of the hands and feet, forearms and legs. Histopathologically, the lesion shows considerable hyperkeratosis, acanthosis, and papillomatosis, mimicking a “church spire”, and a thickened granular layer. It arises in early life, often at birth or infancy.

Fig 1: Multiple nodules brownish verrucous on the dorsum of the feet.
Fig 2: Hyperkeratosis and hypergranulosis with a “church spire” (H&E, ×100).

The only effective treatment of AKV is superficial ablation.


The examination of the patient was conducted according to the Declaration of Helsinki principles.


Source of Support: Nil

Conflict of Interest: None declared.

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