2013.4-29.Eponymsbodies

Dutcher bodies are PAS-positive, diastase-resistant nuclear pseudoinclusions of eosinophilic
cytoplasm found in plasma cells described by Dutcher and Fahey in Waldenstrom
macroglobulinemia. Dutcher bodies are a feature of clinically indolent, mucosa-associated
lymphoid tissue (MALT) lymphomas. There are no essential differences between Dutcher bodies, single or multiple Russell bodies, and the inclusions of Mott cells. They are all aspects of the same phenomenon, representing spherical cytoplasmic inclusions that are either clearly within the cytoplasm or are overlying the nucleus or invaginated into it.
Russell bodies, is named after William Russell (1852-1940), (Fig. 3), Scottish pathologist and physician.Mott cell is named after Mott, who described it in 1905. Dutcher bodies may rarely occur in a benign reactive condition, such as synovitis. While Dutcher bodies may be a clue to the presence of low-grade lymphoma, they are not a definitive feature, particularly in unusual contexts.

Figure 3. William Russell (1852-1940).

Kamino bodies named after contemporary American dermatopathologist, Hideko Kamino, (Fig. 4). They are dull pink areas of trapped basement membrane material within the epidermis seen in Spitz nevi.

Figure 4. Hideko Kamino.

These are inclusion bodies within neurons and the cells of the heart, liver, muscle, and skin, seen in Lafora disease. Lafora disease also called Lafora progressive myoclonic epilepsy is a fatal autosomal recessive disorder. The disease is named after Gonzalo Rodriguez Lafora (1886–1971), (Fig. 5), a Spanish neuropathologist who first recognized small inclusion bodies in Lafora patients in 1911.

Figure 5. Gonzalo Rodriguez Lafora (1886-1971).

Intracytoplasmic, nonflagellated parasites seen in leishmaniasis.
Leishmaniasis is a zoonotic infection caused by protozoa that belong to the genus Leishmania. The disease is named after Leishman, who first described it in London in May 1903. Lieutenant-General Sir William Boog Leishman (1865-1926), (Fig. 6), was a Scottish pathologist and British Army medical officer. In 1901, while examining pathologic specimens of a spleen from a patient who had died of kala azar he observed oval bodies and published his account of them in 1903. Captain Charles Donovan confirmed the finding of what became known as Leishman-Donovan bodies in smears taken from patients in Madras in southern India.

Figure 6. William Boog Leishman (1865-1926). A courtesay of National Library of Medicine.

Concentric, laminated, calcified bodies within and external to the cells seen in Malakoplakia, an inflammatory condition that affects the genitourinary tract.
Leonor Michaelis (1875-1949), (Fig. 7), was a German-American biochemist. Carl Gutmann, was a German physician, born 1872.

Figure 7. Leonor Michaelis (1875-1949).

Cytoplasmic Inclusion bodies found in the purkinje cells of the brain in cases of rabies. It can be seen in the skin.It is named for, Adelchi Negri (1876-1912), (Fig. 8), who was an Italian pathologist, and microbiologist. His teacher was, the Nobel Prize winning Camillo Golgi (1843- 1926).

Figure 8. Adelchi Negri (1876-1912).

This is another name for lamellar granules (otherwise known as membrane-coating granules (MCGs), lamellar bodies, or keratinosomes). They are secretory organelles found in type II pneumocytes and keratinocytes. They are oblong structures, appearing about 300-400 nm in width and 100-150 nm in length in transmission electron microscopy images. Lamellar granules fuse with the cell membrane and release their contents into the extracellular space. Named after, George Odland (1922-1997), (Fig. 9), who was a world expert in skin research and longtime head of the dermatology division at the University of Washington School of Medicine.

Figure 9. George Odland (1922-1997).

Calcium-containing inclusion bodies found in the cytoplasm of giant cells in sarcoidosis,
berylliosis and uncommonly, in Crohn’s disease and tuberculosis. These bodies were first
described by the German physician Oscar von Schüppel (1837-1881) in 1871, and by Max
Askanazy (1865-1940) in 1921 as Kalkdrusen. But it is named for Jörgen Nilsen
Schaumann (1879-1953),(Fig. 10), a Swedish dermatologist. It is to be mentioned that, a number of cytoplasmic structures/inclusions can be identified within the granulomas of sarcoidosis, including asteroid bodies, Schaumann’s bodies, calcium oxalate crystals, and Hamazaki- Wesenberg bodies; the last two of these can cause difficulties in differential diagnosis. Hamazaki-Wesenberg bodies (alternatively termed yellow-brown bodies, yellow bodies, Hamazaki corpuscles) are structures of unknown significance, which have been periodically documented in the sinuses of lymph nodes in numerous anatomic locations and myriad medical conditions, including appendicitis, cirrhosis, lymphoid tumours, colon carcinoma and nume rous others, most famously sarcoidosis. Initially described by Hamazaki in 1938 in mesenteric lymph nodes, 6 and later noted by Menne in 1952 in 70% of mesenteric lymph nodes removed during appendectomies.

Figure 10. Jörgen Nilsen Schaumann (1879-1953). A courtesy of the Hagströmer Medico-Historical Library, Karolinska Institutet, Stockholm, Sweden.

A peculiar microscopic pattern seen in schwannomas, consisting of palisading cell around a
cellular area. It is named after, Jose Juan Verocay (1876-1927), (Fig. 11). He was a Uruguayan physician who trained and worked for most of his adult life in Europe in the late nineteenth and early twentieth century.

Figure 11. Jose Juan Verocay (1876-1927).

WPBs are elongated secretory organelles specific to endothelial cells that contain von Willebrand factor (VWF) and a variety of other proteins that contribute to inflammation, angiogenesis, and tissue repair. Weibel–Palade bodies were initially described, by the Swiss anatomist and biologist, Ewald Rudolf Weibel, born 1929, (Fig. 12), and the Romanian physiologist George Emil Palade (1912- 2008), (Fig. 13). Palade was described as „the most influential cell biologist ever”. In 1974 he was awarded the Nobel Prize in Physiology and Medicine, for his work on the function of organelles in cells together with Albert Claude and Christian de Duve.

Figure 12. Ewald Rudolf Weibel.

Figure 13. George Emil Palade (1912-2008).